ROLE OF ISCHEMIA IN PATHOGENESIS OF STRESS-INDUCED GASTRIC LESIONS IN PIGLETS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 146  (2) , 217-220
Abstract
Ten conscious piglets were subjected to hemorrhagic shock for 3 h. Nine surviving piglets showed severe stress induced gastric mucosal lesions in the gastric fundus and corpus. Total and regional gastric blood flow was measured, 8 micron radioactive microspheres, in the same piglets before (control) and during hemorrhagic shock. Total gastric blood flow fell almost 90% during shock. There was a significantly higher flow reduction in the mucosa of the corpus and fundus, where almost all the stress lesions were found. Measurement of blood flow within these lesions demonstrated a fall approximately to zero. Ischemia seems to be an important pathogenetic factor of gastric stress lesions. This may possibly render the gastric mucosa more susceptible to other injurious factors.

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