THE EFFECT OF CHOLECYSTOKININ ON THE CHOLEDOCHODUODENAL MECHANISM (SPHINCTER OF ODDI)

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Abstract
The most frequent effect on the choledocho-duodenal mechanism of the preparation of cholecystokinin used was to cause an initial increase in the resistance to the flow of fluid from the common bile duct into the duodenum; this was followed by a decrease in resistance. In most instances these changes in resistance are correlated with a periodic increase and decrease in the motility and "tone" of the duodenum. In 4 expts., in which the motor response of the duodenum to the injection of the hormone was delayed, the primary effect was a decrease in resistance, indicating that the primary increase in resistance is due entirely to the increase in the tone of the duodenum and that if the hormone has a specific action on the sphincter of Oddi, it is inhibitory rather than excitatory. These effects are obtained after cholecystectomy and are therefore independent of the gall bladder. Further evidence supporting the concept of a common duct sphincter independent of duodenal activity was noted.

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