Tissue Distribution of Monomeric and Polymeric Plutonium as Modified by a Chelating Agent

Publisher Website
Google Scholar
Abstract
Mice were injected intravenously with Pu citrate in either a monomeric (ionic) state that was almost completely ultrafilterable or a polymeric (colloidal) state, about 1/3 of which was not ultrafilterable. At 3 days intraperitoneal injections of 500 mg/kg of diethylenetriaminepentaacetic acid (DTPA) or of saline were initiated, 1 per day. At 3 days mice given the polymeric solution retained more of the Pu in the liver (45% of the dose) and spleen and less in the bone (20%) than did mice given the monomeric solution (liver 35%; bone 30%). In each case approximately 9 days of DTPA therapy lowered the level of Pu in the bone by about one-half. The liver burden of mice injected with the monomeric form was nearly completely removed after a few days of treatment, but that of mice given the polymeric form was reduced slowly and by only about 1/3.