Enhancement of Sexual Motivation in Male Rats by Yohimbine
- 24 August 1984
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 225 (4664) , 847-849
- https://doi.org/10.1126/science.6474156
Abstract
Yohimbine hydrochloride, an alpha 2-adrenoceptor antagonist, increased sexual motivation in male rats as evidenced by increased mounting performance in mating tests conducted after genital anesthetization, increased percentage of male rats ejaculating in their first heterosexual encounter, and induction of copulatory behavior in sexually inactive male rats. These observations lead to the suggestion that alpha-adrenoceptors are important modulators of sexual arousal in intact male rats. These results indicate that pharmacological treatment of sexual (libido) dysfunction may be useful.Keywords
This publication has 31 references indexed in Scilit:
- Presynaptic mediation by α2-, β1- and β2-adrenoceptors of endogenous noradrenaline and dopamine release from slices of rat hypothalamusLife Sciences, 1983
- The physiological role of α-adrenoceptors in the CNS: new concepts from single-cell studiesTrends in Pharmacological Sciences, 1983
- Effects of pergolide and bromocriptine on male rat sexual behaviorJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1982
- Potentiation of the aphrodisiac effect of N-n-propyl-norapomorphine by naloxoneEuropean Journal of Pharmacology, 1982
- Effects of a novel dopamine-receptor agonist RDS-127 (2-N,N-di-n-propylamino-4,7-dimethoxyindane), on hormone levels and sexual behavior in the male ratPhysiology & Behavior, 1982
- DOPAMINERGIC REVERSAL OF THE DECLINE AFTER CASTRATION OF RAT COPULATORY BEHAVIOURJournal of Endocrinology, 1977
- Regulation of noradrenaline release by presynaptic receptor systemsPublished by Springer Nature ,1977
- The significance of dopamine, versus other catecholamines, for L-DOPA induced facilitation of sexual behavior in the castrated male ratPharmacology Biochemistry and Behavior, 1976
- Role of brain monoamines in male sexual behaviorLife Sciences, 1974
- Compulsive Sexual Activity Induced by p -Chlorophenylalanine in Normal and Pinealectomized Male RatsScience, 1969