Trace Proteins in Biological Fluids. IV. Physicochemical Properties and Sites of Formation of -Trace and -Trace Proteins.

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Abstract
Two isolated trace proteins of beta and gamma mobility from human cerebrospinal fluid were studied to determine their sedimentation coefficients in the ultracentrifuge and their sites of formation. Two sedimentation peaks were obtained for [beta]-trace, 0. 5 S and 2. 1 S, and one for gamma-trace, 1. 6 S. The 2 values for [beta]-trace were thought to be due to polymerization. Production of gamma-trace in vitro occurred in a number of Rhesus monkey tissues, but was most striking in the submaxil-lary gland where the protein was present in extractable amounts. A few cultures of choroid plexus, fimbriae of the Fallopian tube, and testis showed C14-aimno acid incorporation into [beta]-trace.