Demonstration of Lipemia-Clearing Activity After Sublingual Administration of Heparin Potassium in the Rabbit

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Abstract
A standardized method is described for determining the lepemia-clearing activity of sublingually administered heparin in experimental animals. Sublingual administration of heparin potassium produces an eightfold increase in plasma lipemia-clearing activity, essentially equivalent to that produced when the drug is given intravenously. The activation of clearing factor upon sublingual administration occurred without alterations in clotting time.