Decline of Corticosteroid Secretion Following Hypophysectomy.

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Abstract
The cortical steroid content of adrenal venous blood collected from the lumbo-adrenal vein was studied in several dogs before and after hypophysectomy. A decline in the rate of secretion of corticosterone, 17-hydroxycorticosterone and an unknown 17,21-dihydroxy-20-keto-steroid was observed in animals immediately after hypophysectomy. The rate of steroid secretion dropped rapidly during the first 30 minutes. At the end of 1 hour the rate was approximately 50% of the control rate. At the end of 3 hours the rate was 1/6 - 1/10. The rate of steroid secretion in sham-operated animals was variable, but generally significantly higher than those of the hypophysectomized animals. The steroids were analyzed by fluorescence and the phenylhydrazine reaction.

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