Pharmacological Inhibition of Salivary Glands: A Possible Therapy for Sialosis and Sialoadenitis

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Abstract
An increase of α-amylase concentration and specific amylase activity (correlated to protein content) was evident already after 3 days in the parotid glands of rats treated with 2×2 mg/day of propranolol hydrochloride. After separation of amylase into isoenzymes, only the specific isoamylase activities were enhanced. In contrast to treatment with a guanethidine derivative (guanoxane), these changes have persisted after 3 weeks. On the strength of these results, functional inhibition of the salivary glands (i.e. blockade of secretion by β-sympatholytic agents) is discussed as a therapeutical possibility for the management of sialosis and sialoadenitis.