Effect of Cortisone on the Lipids of Bone Matrix in the Rat.

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Abstract
Control, adrenalectomized, cortisone-treated (0.2 ml cortisone acetate per 100 g body weight/day for 10 days), and adrenalectomized, cortisone-treated rats were compared. Adrenalectomy caused a statistically significant decrease in total lipid, total fatty acid, and total cholesterol. Treatment with cortisone caused a statistically significant incrase in all of these fractions with a grater increase being seen in the cortisone-treated, adrenalectomized animal. The cells of osseous tissue respond to cortisone in a fashion which parellels the response of other tissues in the body and that there is an accumulation of lipid following treatment with a decrease in these lipid fractions following adrenalectomy.