ACUTE-LEUKEMIA IN IDIOPATHIC SIDEROBLASTIC ANEMIA - RESPONSE TO COMBINATION CHEMOTHERAPY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 59  (3) , 652-656
Abstract
Three patients with idiopathic sideroblastic anemia of variable duration developed acute leukemia. In 2, the leukemia was morphologically and histochemically myeloblastic and in 1 lymphoblastic. With combination chemotherapy remission was achieved in all 3. The remission inductions were complicated by long periods of bone marrow suppression; the duration of remissions was brief (3, 2 and 3 mo.). Survival after diagnosis was 13, 10 and 9 mo., respectively. The ring sideroblast abnormality persisted during the leukemic and remission phases; transfusion requirements remained unaltered in the 2 patients with transfusion dependent anemia throughout their courses.