Nucleotide sequence of the inverted terminal repetition in adeno-associated virus DNA
- 1 May 1980
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 34 (2) , 402-409
- https://doi.org/10.1128/jvi.34.2.402-409.1980
Abstract
The inverted terminal repetition in adeno-associated virus type 2 DNA has been sequenced. The terminal repetition contain 145 nucleotides of which the first 125 nucleotides can self-base pair to form a T-shaped hairpin structure. Both restriction endonuclease analysis with SmaI and BglI and direct sequence analysis of the SmaI fragments provide evidence for two sequences in the region of the terminal repetition between nucleotides 44 and 81. The two sequences represent an inversion of the first 125 nucleotides of the terminal repetition. Based on these data a model for adeno-associated virus DNA replication is presented which agrees in detail with a general model for eucaryotic DNA replication originally proposed by Cavalier-Smith (T. Cavalier-Smith, Nature [London] 18:672--684, 1976).This publication has 23 references indexed in Scilit:
- Structure of the 3′ hairpin termini of four rodent parvovirus genomes: Nucleotide sequence homology at origins of DNA replicationCell, 1979
- Adeno-associated virus DNA replication: Nonunit-length moleculesVirology, 1979
- The use of thin acrylamide gels for DNA sequencingFEBS Letters, 1978
- Origin and termination of adeno-associated virus DNA replicationVirology, 1977
- Structure and nucleotide sequence of the terminal regions of adeno-associated virus DNAVirology, 1977
- Palindromic base sequences and replication of eukaryote chromosome endsNature, 1974
- Visualization of the inverted terminal repetition in adeno-associated virus DNAJournal of Molecular Biology, 1974
- Arrangement of nucleotide sequences in adeno-associated virus DNAJournal of Molecular Biology, 1973
- Plus and Minus Single-Stranded DNA Separately Encapsidated in Adeno-Associated Satellite VirionsScience, 1969
- Adenovirus-Associated Defective Virus ParticlesScience, 1965