Factor VIII and Factor-VIII-Related Antigen in Multiple Myelomatosis and Related Conditions

Abstract
Factor VIII and factor-VIII-related antigen (FVIIIRA) were estimated in 19 patients with paraproteinemia. The FVIIIRA levels were above the normal range in 12 cases with 11 of these showing an abnormal FVIII/FVIIIRA ratio. The patients were subdivided into 3 groups according to their FVIIIRA levels: normal levels, levels greater than normal but less than 200% and greater than 200%. This subdivision correlated with the degree of bone involvement as assessed by radiological skeletal survey.