CADMIUM AND THE RETICULOENDOTHELIAL SYSTEM (RES) - A SPECIFIC DEFECT IN BLOOD CLEARANCE OF SOLUBLE AGGREGATES OF IGG BY THE LIVER IN MICE GIVEN CADMIUM

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (1) , 17-26
Abstract
The ability of the RES to bind and catabolize soluble stable heat aggregates of 125I-Ig[immunoglobulin]G (A-IgG) was studied in mice given oral Cd. Cd caused a delay in the circulation clearance of A-IgG in intact animals. The defect was due to impaired liver uptake of A-IgG and correlated with increased liver Cd. Subsequent catabolism of bound A-IgG by liver slices was not affected. The defect was specific in that clearance of aggregated human serum albumin and colloidal carbon was normal in Cd mice; this suggests that Cd may affect either Fc or complement receptors of Kupffer cells in the liver.