The Lynch Syndrome: Melding Natural History and Molecular Genetics to Genetic Counseling and Cancer Control
Open Access
- 1 January 1996
- journal article
- research article
- Published by SAGE Publications in Cancer Control
- Vol. 3 (1) , 13-19
- https://doi.org/10.1177/107327489600300101
Abstract
Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural history, particularly early age of onset and the pattern of multiple primary cancer excess, is essential for the diagnosis and management of HNPCC.Keywords
This publication has 34 references indexed in Scilit:
- Cancer statistics, 1995CA: A Cancer Journal for Clinicians, 1995
- Hereditary non-polyposis colorectal cancer — morphologies, genes and mutationsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1994
- Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancerNature, 1994
- Attitudes of neurologists, psychiatrists, and psychotherapists towards predictive testing for Huntington's disease in Germany.Journal of Medical Genetics, 1993
- Predictive testing for Huntington's disease: after the gene. The United Kingdom Huntington's Disease Prediction Consortium.Journal of Medical Genetics, 1993
- Presymptomatic testing for Huntington's disease: a world wide survey. The World Federation of Neurology Research Group on Huntington's Disease.Journal of Medical Genetics, 1993
- Clues to the Pathogenesis of Familial Colorectal CancerScience, 1993
- Randomized Comparison of Surveillance Intervals after Colonoscopic Removal of Newly Diagnosed Adenomatous PolypsNew England Journal of Medicine, 1993
- Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP)Human Molecular Genetics, 1992
- Muir-Torre syndrome in several members of a family with a variant of the Cancer Family SyndromeBritish Journal of Dermatology, 1985