Gene structure of rat cathepsin H
- 14 August 1989
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 253 (1-2) , 103-107
- https://doi.org/10.1016/0014-5793(89)80939-1
Abstract
The gene structure of rat cathepsin H was determined. It comprises at least 12 exons of various lengths (32–433 bp) spanning in total more than 17.5 kbp. The gene structure does not correspond well to the functional unit of the proteinase. The region around the active site Cys residue, the most conserved region among cysteine proteinases, is split by an intron. This is a common characteristic among the gene structures of cysteine proteinases.Keywords
This publication has 12 references indexed in Scilit:
- Biosyntheses and processing of lysosomal cysteine proteinases in rat macrophagesFEBS Letters, 1988
- Molecular cloning and sequencing of cDNA for rat cathepsin H Homology in pro‐peptide regions of cysteine proteinasesFEBS Letters, 1987
- Intracellular transport and processing of lysosomal cathepsin HBiochemical and Biophysical Research Communications, 1987
- Regulation of Inducible and Tissue-Specific Gene ExpressionScience, 1987
- Nucieotlde sequence analysis of alpha-arnylase and thiol protease genes that are hormonally regulated in barley aleurone cellsNucleic Acids Research, 1987
- Dideoxy sequencing method using denatured plasmid templatesAnalytical Biochemistry, 1986
- Gene structure of calcium‐dependent protease retains the ancestral organization of the calcium‐binding protein geneFEBS Letters, 1986
- Characterization of two highly diverged but developmentally co-regulated cysteine proteinase genes inDictyostelium discoideumNucleic Acids Research, 1985
- Homology of amino acid sequences of rat liver cathepsins B and H with that of papain.Proceedings of the National Academy of Sciences, 1983
- Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.Proceedings of the National Academy of Sciences, 1978