Germ‐line configuration of the T‐cell receptor beta‐chain gene in B‐cell chronic lymphoproliferative disorders which co‐express T‐cell antigens

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Abstract
In 7 cases of chronic B-cell lymphoproliferative disorders - 6 chronic lymphocytic leukaemias and 1 non-Hodgkin lymphoma in leukaemic phase - which co-expressed T-cell markers (CD3, CD2) the clonal origin was investigated at the DNA level. In accordance with the diagnosis, all cases showed a monoclonally rearranged configuration of the immunoglobulin genes. On the contrary, the T-cell receptor beta chain gene always retained a germ-line organization. These findings demonstrate that B-cell chronic lymphoproliferative disorder which co-express T-cell-related markers are truly composed of monoclonal B-cell elements.

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