THE REACTION OF HUMAN CHORIONIC AND EQUINE GONADOTROPINS TO NITROUS ACID

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Abstract
Both prolan and pregnant mare serum hormone are relatively stable to 0.1 N nitrous acid at 2[degree] C. At 2[degree] C. and in 0.5 N nitrite conc. (as nitrous acid or in 5% acetic acid), PMS hormone is less stable than is prolan. At room temp. mare serum hormone is progressively inactivated by exposure to nitrite-acetic acid, under conditions in which prolan retains about half its original activity. While failing to establish the essentiality or non-essentiality of the amino group for physiologic activity, the behavior of the 2 hormones to nitrous acid has established a characteristic difference in chemical reactivity.

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