HYPERPLASIA OF THE THYROID GLAND OF RHESUS MONKEYS AFTER THIOURACIL TREATMENT

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Abstract
ADMINISTRATION of thiouracil to rhesus monkeys (Macaca mulatta) causes hyperplasia and colloid depletion in monkeys as it does in other animals and in man. Certain special histological features of thyroid hyperplasia in the monkey are described in this report. Changes in some physiological constants in surgically induced hypothyroid monkeys have been described previously by Fleischman, Shumacker, and Wilkins (1945) and by Jailer, Sperry, Engle, and Smelser (1944). The effect of thiouracil on serum cholesterol, circulation times and white blood cell count of rhesus monkeys was reported by Aranow, Engle, and Sperry (1946). In these studies thiouracil was administered orally to four adult female monkeys in increasing dosage over a period of 14 months. Thiouracil was given daily except Sunday. On Saturday a double quantity was given. The quantity administered was 0.1 gm. for the first 28 days, 0.2 gm. for the next 61 days, and 0.4 gm. for an additional 76 days.

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