SOME EFFECTS OF THE ADMINISTRATION OF THIOURACIL TO MONKEYS1

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Abstract
THE GOITROGENIC effects of thiourea, the sulfonamides and related compounds such as thiouracil have been well known since the reports by the Mackenzies (1941, 1943) and the extensive investigations of Astwood and associates (1943 et seq.). The action of thiouracil in the rat and other lower forms has been discussed by many investigators. The potential therapeutic value of the drug has led to numerous and careful investigations of its action in man (Astwood 1943, 1944 et al.). For further experimental study the adult rhesus monkey (Macaca mulatta) was chosen. Other studies on the effect of hypothyroidism in these animals have been reported from this laboratory (Jailer, Sperry, Engle and Smelser 1944;Engle 1944) and afford several measurements of thyroid function which were useful in this investigation.