Further Studies on 4-Hydroxy-3-Methoxyphenylglycol Oxidation in Humans: Effect of Pool Expansion and Stereochemistry
- 1 August 1983
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 41 (2) , 299-301
- https://doi.org/10.1111/j.1471-4159.1983.tb04743.x
Abstract
The in vivo oxidation of the norepinephrine metabolite 4-hydroxy-3-methoxyphenylglycol (HMPG) to 4-hydroxy-3-methoxymandelic acid was studied in man with two different doses of deuterium-labeled HMPG and a tracer dose of [14C]HMPG. HMPG oxidation appeared to be dose-dependent with an oxidation of 62-70% for doses below or equal to 2.2 .mu.mol. With the use of a capillary column coated with an optically active phase (Chirasil-Val) and gas chromatography mass-spectrometry the human urinary excretions of the 2 stereoisomers of deuterium-labeled HMPG (free + conjugates) were found to be equal.Keywords
This publication has 10 references indexed in Scilit:
- Norepinephrine Metabolism in Humans Studied by Deuterium Labelling: Turnover of 4-Hydroxy-3-methoxyphenylglycolJournal of Neurochemistry, 1983
- Norepinephrine Metabolism in Man Using Deuterium Labeling: Turnover of 4‐Hydroxy‐3‐Methoxymandelic AcidJournal of Neurochemistry, 1982
- Norepinephrine Metabolism in Man Using Deuterium Labelling: The Conversion of 4‐Hydroxy‐3‐Methoxyphenylglycol to 4‐Hydroxy‐3‐Methoxymandelic AcidJournal of Neurochemistry, 1981
- Stereoselective excretion of (3-methoxy-4-sulphooxyphenyl)ethylene glycol (MHPG sulphate) in the dogNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1980
- Some aspects of noradrenaline metabolism in manDrug and Alcohol Dependence, 1980
- Gas chromatographic—mass spectrometric analysis of optically active metabolites and drugs on a novel chiral stationary phaseJournal of Chromatography B: Biomedical Sciences and Applications, 1978
- MASS FRAGMENTOGRAPHIC DETERMINATION OF SOME ACIDIC AND ALCOHOLIC METABOLITES OF BIOGENIC AMINES IN THE RAT BRAINJournal of Neurochemistry, 1975
- Preparation of deuterium labelled catecholamines, catecholamine precursors and metabolites for use as internal standards in mass fragmentographic determination and for turnover studiesJournal of Labelled Compounds and Radiopharmaceuticals, 1974