MONOCLONAL-ANTIBODIES TO RAT SARCOMATA .2. A SYNGENEIC IGG2B ANTIBODY WITH ANTI-TUMOR ACTIVITY
- 1 January 1983
- journal article
- research article
- Vol. 49 (4) , 667-671
Abstract
The IgG2b monoclonal antibody M10/76, which is specific for the Hooded rat fibrosarcoma MC24, was obtained by fusion of the rat myeloma Y3 Ag 1.2.3 with spleen cells from an MC24 tumor-bearing rat. This antibody inhibited lung colonization when MC24 cells were injected i.v. into Hooded rats, and when passively transferred into athymic MC24 tumor bearers, it prevented or considerably reduced the incidence of spontaneous lung metastases in more than half the treated animals.This publication has 14 references indexed in Scilit:
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