Mapping genetic influences on brain fiber architecture with high angular resolution diffusion imaging (HARDI)
- 1 May 2008
- proceedings article
- Published by Institute of Electrical and Electronics Engineers (IEEE)
Abstract
We report the first 3D maps of genetic effects on brain fiber complexity. We analyzed HARDI brain imaging data from 90 young adult twins using an information-theoretic measure, the Jensen-Shannon divergence (JSD), to gauge the regional complexity of the white matter fiber orientation distribution functions (ODF). HARDI data were fluidly registered using Karcher means and ODF square-roots for interpolation; each subject's JSD map was computed from the spatial coherence of the ODFs in each voxel's neighborhood. We evaluated the genetic influences on generalized fiber anisotropy (GFA) and complexity (JSD) using structural equation models (SEM). At each voxel, genetic and environmental components of data variation were estimated, and their goodness of fit tested by permutation. Color- coded maps revealed that the optimal models varied for different brain regions. Fiber complexity was predominantly under genetic control, and was higher in more highly anisotropic regions. These methods show promise for discovering factors affecting fiber connectivity in the brain.Keywords
This publication has 13 references indexed in Scilit:
- Fluid Registration of Diffusion Tensor Images Using Information TheoryIEEE Transactions on Medical Imaging, 2008
- Riemannian Analysis of Probability Density Functions with Applications in VisionPublished by Institute of Electrical and Electronics Engineers (IEEE) ,2007
- Information-Theoretic Analysis of Brain White Matter Fiber Orientation Distribution FunctionsPublished by Springer Nature ,2007
- Q‐ball imagingMagnetic Resonance in Medicine, 2004
- Genetic influences on brain structureNature Neuroscience, 2001
- Genetic regulation of regional microstructure of the corpus callosum in late lifeNeuroReport, 2001
- A global optimisation method for robust affine registration of brain imagesMedical Image Analysis, 2001
- Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imagingMagnetic Resonance in Medicine, 1999
- Bootstrapping Goodness-of-Fit Measures in Structural Equation ModelsSociological Methods & Research, 1992
- Divergence measures based on the Shannon entropyIEEE Transactions on Information Theory, 1991