DNA Ends RecQ-uire Attention
- 13 April 2001
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 292 (5515) , 229-230
- https://doi.org/10.1126/science.1060832
Abstract
From yeast to flies to humans, cells have evolved a conserved series of proteins that repair breaks in the DNA and maintain the ends of chromosomes (telomeres) at a constant length. In their Perspective, Wu and Hickson discuss the part played by the RecQ helicase family of enzymes in maintaining genome stability and explain how mutations in these proteins result in several rare cancer-susceptibility and premature-aging syndromes.Keywords
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