Capillary Permeability During Hemorrhagic Shock in the Rat

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Abstract
Albino rats were subjected to various degrees of hemorrhagic hypotension. Using serial bleedings to 65-70 mm Hg for 15 minutes and then 50 mm Hg for 15 minutes, 60% of the animals survived. The other 40% were considered to be in a state of irreversible hemorrhagic shock. Using this level of hypotension as a standard, capillary permeability was studied using fluorescein labeled bovine albumin conjugate (BAC) as a tracer. Disappearance curves of BAC were plotted for control, surviving and fatal animals. No difference was found in the disappearance rate of BAC in the 3 series.