ON METABOLIC EFFECTS OF DIURETICS AND BETA-BLOCKERS - RESULTS FROM A CLASS-SECTIONAL AND LONGITUDINAL POPULATION STUDY OF WOMEN

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 212  (1-2) , 57-64
Abstract
A population sample of women in Goteborg, Sweden, was studied in 1968-1969 and restudied in 1974-1975. A number of metabolic variables could be studied cross-sectionally (in 1974-1975) and longitudinally (intraindividual changes between 1968-1969 and 1974-1975). [The design allowed both longitidunal and cross-sectional studies of the women taking antihypertensive drugs and a comparison with a normotensive reference group not on drug therapy.] When studied cross-sectionally, increased serum urate concentrations were observed in women on diuretics and increased serum triglycerides in women on .beta.-blockers, compared to other women, while no obvious differences were found in blood glucose and serum cholesterol concentrations or in packed red cell volume (PCV). When studied longitudinally, a slight decrease in serum triglyceride concentration was found in women who started to take diuretics and an increase in women who started to take .beta.-blockers compared to other women. Serum urate concentration tended to increase in women who started to take diuretics and PCV tended to decrease in women who started to take .beta.-blockers. Blood glucose was inimpaired. The differences observed were rather small and seemed unimportant compared to the threat presented by the arterial hypertension itself.

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