PROTECTION BY PANTETHINE, PANTOTHENIC-ACID AND CYSTAMINE AGAINST CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN THE RAT
- 1 February 1990
- journal article
- letter
- Vol. 67 (2) , 289-292
Abstract
The daily ip administration of pantethine (500 mg/kg), pantothenic acid (100 mg/kg) or cystamine (50 mg/kg) for 5 days conferred significant protection against the hepatotoxic and peroxidative actions of a 0.5 mL/kg ip dose of CCl4 in rats. All three treatments lessened the increases in serum ALT and liver TBARS values, and the reductions in serum triglyceride levels, and prevented the development of hepatic steatosis caused by the halocarbon. Pantethine was found to offer the greatest protection.This publication has 12 references indexed in Scilit:
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