INFUSIONS OF MINAXOLONE TO SUPPLEMENT NITROUS OXIDE-OXYGEN ANAESTHESIA. A COMPARISON WITH ALTHESIN

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Abstract
In 19 patients, minaxolone citrate, a water-soluble steroid anaesthetic agent, has been used as a continuous infusion to supplement nitrous oxide anaesthesia. The minimum infusion rate (MIR) was found to be 11.3 μg kg−1 min−1 for patients premedicated with morphine 10mg i.m. and breathing spontaneously 66% nitrous oxide in oxygen. The cardiovascular and respiratory effects were similar to those described in a previous study for Althesin administered under comparable conditions. Recovery from minaxolone was prolonged compared with Althesin, and this may be related both to the water-solubility of the drug, and to its greater apparent volume of distribution.