RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion
- 1 March 1998
- journal article
- review article
- Published by Annual Reviews in Annual Review of Neuroscience
- Vol. 21 (1) , 75-95
- https://doi.org/10.1146/annurev.neuro.21.1.75
Abstract
▪ Abstract Synaptic vesicle exocytosis occurs in consecutive steps: docking, which specifically attaches vesicles to the active zone; priming, which makes the vesicles competent for Ca2+-triggered release and may involve a partial fusion reaction; and the final Ca2+-regulated step that completes fusion. Recent evidence suggests that the critical regulation of the last step in the reaction is mediated by two proteins with opposite actions: synaptotagmin, a Ca2+-binding protein that is essential for Ca2+-triggered release and probably serves as the Ca2+-sensor in fusion, and rab3, which limits the number of vesicles that can be fused as a function of Ca2+ in order to allow a temporally limited, repeatable signal.Keywords
This publication has 80 references indexed in Scilit:
- Isolation and Characterization of a GDP/GTP Exchange Protein Specific for the Rab3 Subfamily Small G ProteinsJournal of Biological Chemistry, 1997
- Syntaxin and synaptobrevin function downstream of vesicle docking in drosophilaNeuron, 1995
- Mechanisms of intracellular protein transportNature, 1994
- Calcium dependence of the rate of exocytosis in a synaptic terminalNature, 1994
- Mutations in the drosophila Rop gene suggest a function in general secretion and synaptic transmissionNeuron, 1994
- A post-docking role for synaptobrevin in synaptic vesicle fusionNeuron, 1994
- The probability of transmitter release at a mammalian central synapseNature, 1993
- SNAP receptors implicated in vesicle targeting and fusionNature, 1993
- rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequenceNeuron, 1991
- The GTPase superfamily: conserved structure and molecular mechanismNature, 1991