Decreased in vitro megakaryocyte colony formation in chronic idiopathic thrombocytopenic purpura
- 1 December 1993
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 85 (4) , 803-804
- https://doi.org/10.1111/j.1365-2141.1993.tb03227.x
Abstract
In vitro megakaryocyte colony formation was studied in 25 patients with chronic idiopathic thrombocytopenic purpura (ITP), and compared to 16 controls. A significantly lower number of megakaryocyte progenitors (CFU-MK) was observed in patients (10.8 +/- 12.0 CFU-MK per 10(5) bone-marrow non-adherent mononuclear cells (NAMC), compared to controls (22.5 +/- 15.4 CFU-MK); P < 0.002. Only six patients had a normal number of CFU-MK. The number of CFU-MK was not correlated to initial platelet count (P = 0.35). These findings indicate that in vitro CFU-MK could be of interest in the diagnosis of chronic ITP, and also could be predictive for chronicity in patients with acute ITP.Keywords
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