IMMUNOFLUORESCENCE STUDY OF SKIN RASH IN PATIENTS WITH DENGUE HEMORRHAGIC-FEVER

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 103  (9) , 463-466
Abstract
Skin biopsy specimens (53) obtained from the cutaneous rashes of patients who had dengue hemorrhagic lever (DHF) were studied by immunofluorescence. Six specimens showed deposits of Ig[immunoglobulin]M, .beta.1C-globulin, dengue antigen [Ag] and fibrinogen during the 1st wk of fever. Some but not all of these components (IgM, .beta.1C, dengue, Ag) were demonstrated in 29 specimens. Of them, 23 yielded negative results. Granular deposits of IgM and .beta.1C appeared in the blood vessel walls of dermal papillae. Dengue Ag was seen in mononuclear cells that were closely infiltrated around the blood vessel wall in dermal papillae. Fibrinogen was located within or about the blood vessels. The cutaneous rashes occurring in DHF may be caused by an immunopathologic process.

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