Solute Migration from Oily Solutions into Glycerol-Gelatin Mixtures

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Abstract
A new technique is reported for the study of migration of solutes from solution in oil to the glycerogelatin walls of soft capsules. The oily solution is applied to the top of a glycerogelatin column contained in a truncated disposable plastic syringe. The column is then extruded from the syringe, cut into slices, each slice analysed and diffusion coefficients calculated. The technique was validated by using bases of differing viscosity, and was used to study the effect of phenolic compounds and polysorbate on the permeability of glycerogelatin bases.