Studies in detoxication

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Abstract
The fate of stilbestrol, hexestrol, and dienestrol was studied in the rabbit. The monoglucuronides of these estrogens and also the benzylamine salts of these glucuronides are described. 70% of stilbestrol and hexestrol are excreted combined with glucuronic acid. The 3 estrogens do not affect the ethereal sulfate and neutral sulfur level of rabbit urine. There is no indication that stilbestrol is degraded in vivo to single ring compounds. The isolation of [rho]-glucuronosidodiphenyl from the urine of a rabbit receiving p-hydroxydiphenyl is described.