Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase
- 1 January 1992
- journal article
- research article
- Published by Wiley in Molecular Carcinogenesis
- Vol. 6 (4) , 238-242
- https://doi.org/10.1002/mc.2940060404
Abstract
Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation-, but not chemically-induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation.Keywords
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