Production and purification ofPenicillium citreoviride toxin and its effect on tpp-dependent liver transketolase
- 1 October 1981
- journal article
- research article
- Published by Springer Nature in Folia Microbiologica
- Vol. 26 (5) , 408-412
- https://doi.org/10.1007/bf02927336
Abstract
The production isolation and purification of a yellow mycotoxin fromPenicillium citreoviride NRRL 2579 in different culture media was described. When injected subcutaneously to albino rats it alters the kinetic pattern of transketolase (EC 2.2.1.1) in liver in vivo in a competitive manner. In vitro, the inhibition is noncompetitive in nature. However, addition of thiamine diphosphate (TPP) to the m vitro system relieved the inhibitory effect. These findings suggested a relationship between citreoviridininduced beriberi and the probable antithiamine effect of the toxin.Keywords
This publication has 7 references indexed in Scilit:
- Isolation, partial characterisation of antithiamine factor present in rice-bran and its effect on TPP-transketolase system and Staphylococcus aureus.1976
- ANTI-THIAMINE FACTOR IN COTTON SEED (BOMBEX-MALABERICUM) - ITS ISOLATION AND CHARACTERIZATION1976
- Isolation and characterisation of a crystalline antithiamine factor from mustard seed, Brassica junceaBiochimica et Biophysica Acta (BBA) - General Subjects, 1974
- Regulation of hepatic transketolase activity by thiamin.1973
- Mycotoxic origin of cardiac beriberiJournal of Stored Products Research, 1969
- The structure of citreoviridin, a toxic compound produced byTetrahedron Letters, 1964
- The Determination of Enzyme Dissociation ConstantsJournal of the American Chemical Society, 1934