TREATMENT OF PANIC DISORDER AND AGORAPHOBIA WITH CLONAZEPAM
- 1 May 1986
- journal article
- research article
- Vol. 47 (5) , 238-242
Abstract
Clonazepam, a high-potency benzodiazepine marketed for the treatment of minor motor epilepsy, was used to treat 50 patients with panic disorder (N = 22) or agoraphobia with panic attacks (N = 28). Of the 50 patients, 41 had previously been poorly responsive to standard pharmacologic therapies. At a mean dose of only 1.9 (.+-. 1.0) mg/day, 39 patients (78%) responded. No serious adverse effects were encountered. This study, although retrospective and uncontrolled, suggests that clonazepam, like alprazolam, may be effective in blocking panic attacks. A possible common mechanism for the two drugs as high-potency benzodiazepines is discussed.This publication has 3 references indexed in Scilit:
- Comparison of alprazolam, imipramine, and placebo in the treatment of depressionJAMA, 1983
- Alprazolam in the treatment of generalized anxiety and panic disorders: A double-blind placebo-controlled studyPsychopharmacology, 1982
- MULTI-CENTER DOUBLE-BLIND EFFICACY AND SAFETY STUDY COMPARING ALPRAZOLAM, DIAZEPAM AND PLACEBO IN CLINICALLY ANXIOUS PATIENTS1981