Effects of protamine on histamine release from human lung
- 1 August 1989
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 28 (1-2) , 70-72
- https://doi.org/10.1007/bf02022982
Abstract
Animal mast cell models demonstrate direct histamine release by protamine. Investigators have proposed that protamine also releases histamine in man. We studied the effects of protamine alone and heparinprotamine mixtures on minced lung tissue for evidence of histamine release. We were unable to demonstrate the release of histamine despite positive anti-IgE controls. Nonimmunologic histamine release from human lung appears unlikely as a mechanism for portamine reactions in man.This publication has 15 references indexed in Scilit:
- C5a and Thromboxane Generation Associated with Pulmonary Vaso- and Broncho-constriction during Protamine Reversal of HeparinAnesthesiology, 1987
- Functional heterogeneity of human mast cells from different anatomic sites: In vitro responses to morphine sulfate1Journal of Allergy and Clinical Immunology, 1987
- Protamine: a review of its toxicity.1985
- ProtamineAnesthesia & Analgesia, 1985
- Comparison of Histamine Release in Human Skin Mast Cells Induced by Morphine, Fentanyl, and OxymorphoneAnesthesiology, 1985
- Cardiovascular effects of protamine sulfate are dependent on the presence and type of circulating heparinThe Journal of Thoracic and Cardiovascular Surgery, 1985
- Inflammatory mediators and mechanisms of release from purified human basophils and mast cellsJournal of Allergy and Clinical Immunology, 1984
- DEVELOPMENT OF A SENSITIVE RADIOASSAY OF HISTAMINE FOR INVITRO ALLERGY TESTING1984
- Effects of infused histamine: Correlation of plasma histamine levels and symptomsJournal of Allergy and Clinical Immunology, 1982
- Histamine release from rat mast cells induced by protamine sulfate and polyethylene imineInflammation Research, 1981