The Relation of Factors XII, XI, and IX to Hypercoagulable States

Abstract
Evidence has been obtained in rabbits that the reduction of the silicone whole blood clotting time to the normal glass range reflects a hypercoagulable state attributable to circulating activated factors XII and XI. The potential clinical implications of these findings are discussed. * This study was supported by research grants H-1027 and HTS-5235 from the National Institutes of Health and by a grant-in-aid from the American Heart Association. ** Presented in part before American Physiological Society, Atlantic City, New Jersey, April 15, 1962.

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