Effect of Cortisone on Permeability of the Neonatal Rat Lung to Drugs
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Neonatology
- Vol. 40 (1-2) , 99-104
- https://doi.org/10.1159/000241477
Abstract
The effect of cortisone (5 mg/animal i.p. on day 5 after birth) on the development of adult-type permeability characteristics in the lung was investigated in rats 6–18 days of age. In both treated and control rats, the lipid-soluble drug procainamide was absorbed at similar rates in all age groups. In contrast, in cortisone-treated animals, pulmonary absorption rates for the lipid-insoluble compounds mannitol and p-aminohippuric acid declined to adult levels at the age of 6 days, which was 12 days earlier than in controls. Cortisone treatment thus accelerates development of adult permeability characteristics in the pulmonary epithelium.Keywords
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