Evidence that Medium-Chain Fatty Acid Oxidation Can Support an Active Gluconeogenesis in the Suckling Newborn Rat

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Abstract
Long-chain fatty acid oxidation was inhibited in 1-day-old suckling rats by 2-tetradecylglycidic acid. Within 6 h it induced profound hypoketonemia and hypoglycemia together with a decreased rate of gluconeogenesis estimated from [U-14C]-lactate incorporation into glucose. Medium-chain triglyceride feeding restored, within 3 h, normal blood concentrations of ketones and glucose, as well as a high gluconeogenic rate from [U-14C]-lactate. In the suckling newborn rat 2-tetradecylglucidic acid is effective in inhibiting selectively long-chain fatty acid oxidation and medium-chain fatty acid oxidation can support an active gluconeogenesis.