The structural basis for in situ activation of DNA alkylation by duocarmycin SA
- 28 July 2000
- journal article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 300 (5) , 1195-1204
- https://doi.org/10.1006/jmbi.2000.3887
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SAJournal of Molecular Biology, 1997
- Duocarmycin SA Shortened, Simplified, and Extended Agents: A Systematic Examination of the Role of the DNA Binding SubunitJournal of the American Chemical Society, 1997
- Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activationBioorganic & Medicinal Chemistry, 1997
- A comparative study of the solvolysis reactivity, regioselectivity, and stereochemistry of the duocarmycin a and sa alkylation subunitsBioorganic & Medicinal Chemistry Letters, 1996
- CC‐1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic StudiesAngewandte Chemie International Edition in English, 1996
- Characterization of a CPI-Lexitropsin Conjugate-Oligonucleotide Covalent Complex by 1H NMR and Restrained Molecular Dynamics SimulationJournal of the American Chemical Society, 1995
- Role of the CC-1065 and Duocarmycin N2 Substituent: Validation of a Direct Relationship between Solvolysis Chemical Stability and in vitro Biological PotencyJournal of the American Chemical Society, 1994
- Total synthesis and preliminary evaluation of (+)- and ent-(-)-duocarmycin SAJournal of the American Chemical Society, 1993
- Determination of nucleic acid backbone conformation by proton NMRBiochemistry, 1992
- Molecular basis for sequence-specific DNA alkylation by CC-1065Biochemistry, 1988