Effect of Cimetidine on Exogenous Histamine Inhibition of Histamine Release in Vivo

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Abstract
Exogenous histamine inhibits in vivo histamine release and eosinophil accumulation in ragweed-challenged skin sites of sensitive human subjects. The mechanism(s) involved are unclear. Similar approaches were repeated in 4 of the same subjects pretreated for 3 days with cimetidine, an H2 receptor antagonist. The pattern of exogenous histamine effects was not different in that local exogenous histamine (50 ng/ml) did not significantly alter ragweed-induced mast cell alteration, histamine release, or the deegree of eosinophil accumulation in skin challenge sites. The observed exogenous histamine inhibitory effects may be mediated through the H2 receptor.