SKIN PERMEABILITY AND PREGNANCY

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Abstract
The rate of spread of intradermally injd. hemoglobin is reduced in 4-week-pregnant but not 3-week-pregnant rabbits, whether or not hyaluronidase is added to the hemoglobin. The rate of absorption of fluorescein is increased. Spread is also inhibited if the animals are sacrificed before study; but fluorescein absorption is unaffected in dead pregnant rabbits as compared to dead nonpregnant ones. In the mouse, pregnancy had no detectable effect on spread or absorption.