Use of Hamster Hepatocytes To Metabolize Carcinogens in an in Vitro Bioassay2
- 1 August 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 63 (2) , 519-524
- https://doi.org/10.1093/jnci/63.2.519
Abstract
Adult Syrian golden hamster hepatocytes were shown to have a high capacity to metabolize carcinogens, such as diethylnltrosamine, 2-nitrofluorene, and 4-aminoazobenzene, to a form that transforms mammalian cells. The addition of hepatocytes to the hamster embryo cell transformation system extends its range of usefulness for detecting carcinogens that require metabolic activation.Keywords
This publication has 7 references indexed in Scilit:
- A Comparison of Benzo(A)Pyrene-4,5-Epoxide Hydrase Activity in Hamster Embryo Cells, Hepatocytes and Livers Using High-Pressure Liquid ChromatographyJournal of Liquid Chromatography, 1979
- A High Pressure Liquid Chromatography Procedure for the Separation of Metabolites of 2-Acetylaminofluorene from Cells in CultureJournal of Liquid Chromatography, 1978
- Differences between products of binding of 7,12-dimethylbenz[a]anthracene to DNA in mouse skin and in a rat liver microsomal systemBiochemical and Biophysical Research Communications, 1978
- Rat Hepatocyte Primary Cell Culture-Mediated Mutagenesis of Adult Rat Liver Epithelial Cells by ProcarcinogensExperimental Biology and Medicine, 1977
- Morphological transformation of early passage Golden Syrian Hamster embryo cells derived from cryopreserved primary cultures as a reliable in vitro bioassay for identifying diverse carcinogensInternational Journal of Cancer, 1977
- MICROSOME-MEDIATED MUTAGENESIS IN V79 CHINESE-HAMSTER CELLS BY VARIOUS NITROSAMINES1977
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951