Vascular Responses in Normal Canine Carotid Arteries

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Abstract
Cha S-H, Han MH, Choi YH, et al. Vascular responses in normal canine carotid arteries: Comparison between various self-expanding stents of the same unconstrained size. Invest Radiol 2003;38:95–101. Rationale and Objectives. To compare long-term vascular responses upon the insertion of various self-expandable stents, all the same unconstrained size, in canine carotid artery models. Materials and Methods. Twenty-two stents (5 SMARTs, 5 Wallstents, 6 Niti-Ss, 6 Niti-Ds) of the same unconstrained size (6 mm in diameter, 20 mm in length) were endovascularly placed in canine common carotid arteries. The luminal changes were measured on three occasions, on prestenting, immediate poststenting, and angiograms taken before specimens were killed. After en-bloc harvest of the stented carotid arteries at 6 months, the intraluminal surface was evaluated by gross observation and scanning electron microscopy (SEM). Neointimal thickness was measured at several points both over the wire and between the wires. Results. Niti-D was excluded from analysis because of high rate of poststenting occlusion. SMART stent showed the greatest expansibility with average initial luminal gain (P < 0.05) of 21.2% (Niti-S: 16.5%, Wallstent: 12.9%). At 6 months follow-up, the dilated arterial lumen had returned almost to the prestenting caliber without any significant differences among the stent types (P > 0.05). The thickness of neointimal coverage was more prominent with SMART stent (354 μm over the wire and 258 μm between the wires) than Niti-S (228 μm and 83 μm) or Wallstent (187 μm and 78 μm). Conclusion. Stent types with its higher initial luminal gain appeared to be associated with thicker neointimal formation at 6 months. The acute expanding force of a self-expanding stent may be the key to the cause of neointimal hyperplasia. Regardless of the inserted stent type, the variations in neointimal response were offset by luminal gains of varying degree, thus preserving the arterial patency almost to the prestenting size.

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