The Synthesis of Natural Acetylenic Compounds from Eutypa lata (Pers; F.) TUL
- 10 February 1993
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 76 (1) , 425-430
- https://doi.org/10.1002/hlca.19930760126
Abstract
The synthesis of a series of novel acetylenic compounds 1–7, isolated recently from the fungus Eutypa lata, is described. The crucial step is the coupling reaction between a protected aryl halogenide and the acetylenic chain as a cuprous acetylide (Scheme 1). A more efficient method using bis(triphenylphosphine)palladium dichloride ([Pd(PPh3)2Cl2]) as catalyst was also carried out with success.Keywords
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