Influence of Nutrient and Energy Deprivation on Cellular Response to Single and Fractionated Heat Treatments

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Abstract
The effect of hypoglycemia and hypoxia on cell survival following single and fractionated 44.degree. C heat treatments was investigated. Short-term glucose deprivation or O2 deprivation evidently does not increase sensitivity to single or fractionated heat treatments compared to normal nutrient conditions. However, simultaneous hypoglycemia and hypoxia leads to an increased sensitivity to single heat treatments, and to an even greater increase in sensitivity to fractionated heat treatments. Sensitivity to heat treatment under nutrient-deprived conditions correlates with intracellular ATP levels at the time of treatment. Apparently, it is not nutrient concentration per se, but rather the effect of nutrient level on intracellular ATP concentration that affects thermal sensitivity.