SELECTIVE KILLING OF GLUCOSE AND OXYGEN-DEPRIVED HELA-CELLS BY HYPERTHERMIA

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (10) , 3459-3462
Abstract
Glucose deprivation specifically enhances cell killing by hyperthermia in the absence of oxygen. The interplay of glucose and oxygen on cell killing by hyperthermia (37-42.degree. C) for up to 4 h under varying concentrations of glucose (0-1 mg/ml) and oxygen (0-21%) were evaluated. pH 7.4 was maintained in all trials. In the absence of oxygen, enhanced cell killing at 40 and 42.degree. C was seen with glucose concentrations below 0.1 and 0.25 mg/ml of media, respectively. In the absence of glucose, enhanced killing was seen when oxygen concentrations were below 1 and 2% at 40 and 42.degree. C, respectively. The radiosensitivity of the cells was influenced only by the oxygen concentration during irradiation and not by glucose. Oxygen and glucose are important modifying factors of cell lethality by hyperthermia.