Genetic Linkage and Hemochromatosis

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Abstract
The two articles on hemochromatosis in this issue, by Beaumont and her colleagues from Rennes, France, and by Cartwright and his associates from Salt Lake City, Utah, show how genetic-linkage studies can be used to clarify the mode of inheritance and to determine the presence of the gene for hemochromatosis before the appearance of clinical symptoms. In addition to providing new data on the genetics and pathogenesis of hemochromatosis, these articles describe a powerful methodology that should become increasingly important in medical research.Historically, the mode of inheritance of idiopathic hemochromatosis has been difficult to determine because of the late . . .

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