Linkage of Bipolar Disorder to Chromosome 18q and the Validity of Bipolar II Disorder
Open Access
- 1 November 2001
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 58 (11) , 1025-1031
- https://doi.org/10.1001/archpsyc.58.11.1025
Abstract
ONE OF the great challenges of research in psychiatry lies in the heterogeneity of the clinical entities.1 When clinical heterogeneity reflects a diversity of causes at the genetic level, the power to detect susceptibility loci by genetic linkage analysis is greatly reduced. As yet, there is no valid and reliable means of dividing clinical entities such as bipolar affective disorder (BPAD) into genetically simpler subtypes.Keywords
This publication has 23 references indexed in Scilit:
- A haplotype-based study of lithium responding patients with bipolar affective disorder on the Faroe IslandsPsychiatric Genetics, 1999
- Lithium responsive bipolar disorder, unilineality, and chromosome 18: A linkage studyAmerican Journal of Medical Genetics, 1999
- A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2Proceedings of the National Academy of Sciences, 1999
- Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German familiesMolecular Psychiatry, 1999
- Linkage of Bipolar Affective Disorder to Chromosome 18 Markers in a New Pedigree SeriesAmerican Journal of Human Genetics, 1997
- Linkage analysis of families with bipolar illness and chromosome 18 markersBiological Psychiatry, 1996
- Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23Nature Genetics, 1996
- Genetic dissection of complex traits: guidelines for interpreting and reporting linkage resultsNature Genetics, 1995
- Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.Proceedings of the National Academy of Sciences, 1994
- Die erscheinungsformen des IrreseinsZeitschrift für die gesamte Neurologie und Psychiatrie, 1920