Mycobacterium tuberculosis ecology in Venezuela: epidemiologic correlates of common spoligotypes and a large clonal cluster defined by MIRU-VNTR-24
Open Access
- 6 August 2009
- journal article
- Published by Springer Nature in BMC Infectious Diseases
- Vol. 9 (1) , 122
- https://doi.org/10.1186/1471-2334-9-122
Abstract
Tuberculosis remains an endemic public health problem, but the ecology of the TB strains prevalent, and their transmission, can vary by country and by region. We sought to investigate the prevalence of Mycobacterium tuberculosis strains in different regions of Venezuela. A previous study identified the most prevalent strains in Venezuela but did not show geographical distribution nor identify clonal genotypes. To better understand local strain ecology, we used spoligotyping to analyze 1298 M. tuberculosis strains isolated in Venezuela from 1997 to 2006, predominantly from two large urban centers and two geographically distinct indigenous areas, and then studied a subgroup with MIRU-VNTR 24 loci.Keywords
This publication has 43 references indexed in Scilit:
- Utility of New 24-Locus Variable-Number Tandem-Repeat Typing for Discriminating Mycobacterium tuberculosis Clinical Isolates Collected in BulgariaJournal of Clinical Microbiology, 2008
- Evaluation and Strategy for Use of MIRU-VNTRplus, a Multifunctional Database for Online Analysis of Genotyping Data and Phylogenetic Identification ofMycobacterium tuberculosisComplex IsolatesJournal of Clinical Microbiology, 2008
- Use of cluster-graphs from spoligotyping data to study genotype similarities and a comparison of three indices to quantify recent tuberculosis transmission among culture positive cases in French Guiana during a eight year periodBMC Infectious Diseases, 2008
- Application of Sensitive and Specific Molecular Methods To Uncover Global Dissemination of the Major RD Rio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis Spoligotype FamilyJournal of Clinical Microbiology, 2008
- Discovery of a Novel Mycobacterium tuberculosis Lineage That Is a Major Cause of Tuberculosis in Rio de Janeiro, BrazilJournal of Clinical Microbiology, 2007
- First Molecular Epidemiology Study ofMycobacterium tuberculosisin Burkina FasoJournal of Clinical Microbiology, 2007
- First insight into Mycobacterium tuberculosis genetic diversity in ParaguayBMC Microbiology, 2007
- Spoligotype Signatures in the Mycobacterium tuberculosis ComplexJournal of Clinical Microbiology, 2007
- Proposal for Standardization of Optimized Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing ofMycobacterium tuberculosisJournal of Clinical Microbiology, 2006
- Mycobacterium tuberculosis Beijing Genotype Emerging in VietnamEmerging Infectious Diseases, 2000